Does adverse histopathological features like perineural invasion, depth of invasion and lymphovascular invasion warrant adjuvant treatment in early oral squamous cell carcinoma?
نویسندگان
چکیده
منابع مشابه
Predictors of Thyroid Gland Invasion in Laryngeal Squamous Cell Carcinoma
Introduction: Laryngeal squamous cell carcinoma (SCC) can invade the thyroid gland leading to unnecessary thyroidectomies with subsequent hypothyroidism and hyperparathyroidism. Thus, clinicopathological variables should be defined in order to predict thyroid gland invasion preoperatively. Materials and Methods: We performed a retrospective analysis of 1,465 patients with laryngeal SCC referr...
متن کاملA clinicopathological study of perineural invasion and vascular invasion in oral tongue squamous cell carcinoma.
The risk factors for recurrence of head and neck cancer are classified as being of high or intermediate risk. Those of intermediate risk include multiple positive nodes without extracapsular nodal spread, perineural/vascular invasion, pT3/T4 primary tumours, and positive level IV/V nodes. However, little evidence is available to validate these intermediate risk factors. We analyzed perineural/v...
متن کاملAdjuvant radiotherapy for early head and neck squamous cell carcinoma with perineural invasion: A systematic review.
Perineural invasion (PNI) is widely regarded as a negative prognostic factor in head and neck squamous cell carcinoma (HNSCC). Treatment guidelines recommend adjuvant radiotherapy (RT) for patients with adverse pathologic features, including PNI. The purpose of this study was to systematically review the literature to determine if patients with PNI as their only indication for adjuvant therapy ...
متن کاملPerineural invasion in oral squamous cell carcinoma: a discussion of significance and review of the literature.
Perineural invasion (PNI) is a tropism of tumor cells for nerve bundles in the surrounding stroma. It is a form of tumor spread exhibited by neurotropic malignancies that correlates with aggressive behavior, disease recurrence and increased morbidity and mortality. Oral squamous cell carcinoma (OSCC) is a neurotropic malignancy that traditionally has been difficult to treat and manage. Evidence...
متن کاملPerineural Invasion in Squamous Cell Carcinoma of the Oral Cavity: Histology, Tumor Stage, and Outcome.
OBJECTIVES/HYPOTHESIS To analyze the impact of different types of perineural invasion (PNI) in squamous cell carcinoma (SCC) of the oral cavity on overall survival and recurrence rate, with a special focus on histologic subtypes and tumor stage. STUDY DESIGN Retrospective case-control study with clinicopathological analysis. METHODS Seventeen patients who received primary surgical treatment...
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ژورنال
عنوان ژورنال: Journal of Head & Neck Physicians and Surgeons
سال: 2017
ISSN: 2347-8128
DOI: 10.4103/jhnps.jhnps_41_17